Inability of a man (or male partner in a couple) to cause pregnancy after 12 months of regular, unprotected sexual intercourse is defined as male infertility. Infertility can be caused by female, male, or both. In clinical practice, the male factor is often present either alone or together with female factors.1,2
The prevalence of infertility in India is rising steadily, with male-factor playing a major role in it.2,4
Several factors have been linked with male infertility.
Low sperm count — oligozoospermia
Poor motility — asthenozoospermia
Abnormal morphology — teratozoospermia
Absence of sperm — azoospermia2,5
Defects such as GnRH deficiency, Kallmann or Klinefelter syndrome and Y-chromosome microdeletions can lead to male infertility1
Smoking, alcohol consumption, heat exposure, certain drugs, pollutants are responsible for lowering semen quality1
Couples should consult a doctor before starting any steps or new treatment. Semen analysis is the primary diagnostic tool in the laboratory evaluation of male infertility.1
Many causes of male infertility are treatable or manageable with medical, surgical or assisted reproductive techniques. Lifestyle changes (smoking cessation, weight management and reducing heat exposure) may improve outcomes1,2
Psychological support and counselling are important. Reducing stigma, offering couple-based counselling, and educating families can improve help-seeking and mental-health outcomes7
1. Leslie SW, Hussain MA, Nelson L. Male Infertility. Available from: Male Infertility - StatPearls - NCBI Bookshelf. Accessed on: 12 Aug 2025.
2. Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci. 2015;8(4):191–6.
3. Agiwal V, Madhuri RS, Chaudhuri S. Infertility burden across Indian states: insights from a nationally representative survey conducted during 2019–21. Journal of Reproduction & Infertility. 2023;24(4):287.
4. Huang B, Wang Z, Kong Y, Jin M, Ma L. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health. 2023;23(1):2195.
5. Standard Treatment Workflows of India. Available from: 1726568410_infertility_all.pdf. Accessed on: 12 Aug 2025.
6. Tholeti P, Uppangala S, Kalthur G, Adiga SK. The landscape of assisted reproductive technology access in India. Reprod Fertil. 2024;5(4):e240079.
7. Kaushal R, Gurnani N, Kumar M, Dada R, Kumar R. Male infertility in India: Demographics, aetiology and outcomes of standard clinical practice. National Medical Journal of India. 2020;33(6).
8. Agarwal A, Srivastava A, Fathima F, Lodhi B. Insight into epidemiology of male infertility in central India. IJRCOG. 2022;12(1):215.